Mucoadhesive In Situ Rectal Gel Loaded with Rifampicin: Strategy to Improve Bioavailability and Alleviate Liver Toxicity
Although it is a front-line in tuberculosis treatment, rifampicin (RF) exhibits poor oral sophie allport bee curtains bioavailability and hepatotoxicity.Rectal mucoadhesive and in situ rectal gels were developed to overcome drug drawbacks.A RF/polyethylene glycol 6000 co-precipitate was first prepared in different ratios.Based on the drug solubilit