MUCOADHESIVE IN SITU RECTAL GEL LOADED WITH RIFAMPICIN: STRATEGY TO IMPROVE BIOAVAILABILITY AND ALLEVIATE LIVER TOXICITY

Mucoadhesive In Situ Rectal Gel Loaded with Rifampicin: Strategy to Improve Bioavailability and Alleviate Liver Toxicity

Although it is a front-line in tuberculosis treatment, rifampicin (RF) exhibits poor oral sophie allport bee curtains bioavailability and hepatotoxicity.Rectal mucoadhesive and in situ rectal gels were developed to overcome drug drawbacks.A RF/polyethylene glycol 6000 co-precipitate was first prepared in different ratios.Based on the drug solubilit

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Case report: Bipolar disorder in 48,XXYY syndrome

48,XXYY syndrome is a rare condition.The presentations of impulsive and aggressive behavior have been reported in several case reports among patients with 48,XXYY syndrome.The management of the psychological impact and neuropsychiatric sequela of this condition is a significant issue faced by families, carers, and healthcare professionals.We report

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New Insights Into the Polar Lipid Composition of Extremely Halo(alkali)philic Euryarchaea From Hypersaline Lakes

We analyzed the polar membrane lipids of 13 strains of halo(alkali)philic euryarchaea from hypersaline lakes.Nine belong to the class Halobacteria, representing two functional groups: aerobic polysaccharide utilizers and sulfur-respiring anaerobes.The other four strains represent halo(alkali)philic methanogens from the class Methanomicrobia and a r

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Research Progress of Citrus Melanose

Citrus melanose consists of a series of plant diseases caused by the fungal species of the genus Diaporthe.It has been reported with over 30 Diaporthe species on citrus, including several important fungal pathogens, endophytes, saprophytes, and also latent fungal pathogens with an endophytic/saprophytic lifestyle.Among them, the disease symptoms so

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